1 Twelve years later, the US Food and Drug Administration (FDA)

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pandora charms After propensity score matching, patients who received the surgery with mesh had a higher chance of having a reintervention within one year (mesh 3.3% v no mesh 2.2%, hazard ratio 1.47 (95% confidence interval 1.21 to 1.79)) and were more likely to have urinary retention within 90 days (mesh 7.5% v no mesh 5.6%, risk ratio 1.33 (95% confidence interval 1.18 to 1.51)), compared with those who received surgery without mesh. In subgroup analyses based on age, mesh use was associated with an increased risk of reintervention within one year in patients under age 65 years, and increased risk of urinary retention in patients aged 65 years and over.Conclusions Despite multiple warnings released by the US Food and Drug Administration since 2008, use of mesh in pelvic organ prolapse surgery continues to grow. In this statewide comprehensive study, mesh procedures were associated with an increased risk of reinterventions within one year and urinary retention after surgery.IntroductionIn 1996, the first mesh a synthetic graft was approved for the surgical treatment of incontinence by reinforcing weakened tissue.1 Twelve years later, the US Food and Drug Administration (FDA) released a public health notification that placed the use of mesh for pelvic organ prolapse (POP) under national scrutiny.2 In 2011, the FDA updated safety communication and added a caution for transvaginal placement of mesh in POP surgery, reporting 1503 events from the Manufacturer and User Facility Device Experience (MAUDE) database from 1 January 2008 to December 2010 associated with mesh repair.3 4 In addition, the FDA alerted that complications increased fivefold over time.5 Subsequently, the safety of surgical mesh has been the target of major media coverage6 7 and has led to several lawsuits.8POP occurs when the uterus or vaginal walls weaken and descend pandora necklaces, causing a variety of symptoms including pressure, pain, bleeding, and incontinence pandora charms.

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